Hi there,
I am on macOS Monterey, on a 2020 mac mini M1.
Until yesterday, no problem opening touchdesigner, but suddenly it doesnt load, and displays this problem.
I rebooted the computer, still doesn’t work.
All right - I installed the latest Python 2 release, and it works again. In case anybody else runs into this problem, here is the download page :
Phew! 
That’s really odd since I thought TD shipped with its own version and separate installation of Python? At least that is the case on the Windows version.